Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.

ABSTRACT:

Background

Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node.

Methods and results

The most commonly used animal model of pulmonary hypertension, the monocrotaline-injected rat, was used. The functional consequences of monocrotaline injection were determined by echocardiography, ECG recording, and electrophysiological experiments on the Langendorff-perfused heart and isolated AV node. The ion channel transcriptome was measured by quantitative PCR, and biophysically detailed computer modeling was used to explore the changes observed. After monocrotaline injection, echocardiography revealed the pattern of pulm

SUBMITTER: Temple IP 

PROVIDER: S-EPMC5679363 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature