Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly.

ABSTRACT:

Objective

To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline.

Methods

One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of 4 years. SCD and affective measures were generated from the Geriatric Depression Scale (GDS) with factor analysis on data from a larger set of 347 healthy, nondepressed (GDS <11) elderly individuals. Cognition was summarized with previously validated factor scores. Pittsburgh compound B (PiB)-PET scans were acquired to determine the presence (PiB+) or absence (PiB-) of Aβ pathology. Mixed models were used to assess the independent and interactive effects of SCD, affective features, PiB status, and tim

SUBMITTER: Vogel JW 

PROVIDER: S-EPMC5679415 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature