Riluzole Serum Concentration in Pediatric Patients Treated for Obsessive-Compulsive Disorder.

ABSTRACT:

Purpose/background

The goals of this study were to determine whether pediatric serum concentration of riluzole is similar to that observed in adults and to determine whether riluzole serum concentration is associated with adverse effects or efficacy in children and adolescents with treatment-refractory obsessive-compulsive disorder.

Methods/procedures

Data were drawn from previously published studies: 1 open-label trial and 1 randomized controlled trial with an open-label extension phase. Serum was drawn at 24, 36, and 52 weeks in 37 patients who were taking approximately 100 mg riluzole daily (mean dose at 24 weeks, 99 ± 28 mg).

Findings/results

Across all samples, serum riluzole concentration ranged from 7 to 963 ng/mL. At week 24 (n = 37), the median concentration

SUBMITTER: Grant P 

PROVIDER: S-EPMC5679444 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature