Arterio-venous fetoplacental vascular geometry and hemodynamics in the mouse placenta.

ABSTRACT:

Introduction

The fetoplacental vasculature network is essential for the exchange of nutrients, gases and wastes with the maternal circulation and for normal fetal development. The present study quantitatively compares arterial and venous morphological and functional differences in the mouse fetoplacental vascular network.

Methods

High resolution X-ray micro-computed tomography was used to visualize the 3D geometry of the arterial and venous fetoplacental vasculature in embryonic day 15.5 CD-1 mice (n = 5). Automated image analysis was used to measure the vascular geometry of the approximately 4100 arterial segments and 3200 venous segments per specimen to simulate blood flow through these networks.

Results

Both the arterial and venous trees demonstrated a hierarchical

SUBMITTER: Rennie MY 

PROVIDER: S-EPMC5679460 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature