Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background

Reliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking. We investigated the relationship between plasma cytokine levels and features of NAFLD histology to gain insight into cellular pathways driving NASH and to identify potential non-invasive discriminators of NAFLD severity and pattern.

Methods

Cytokines were measured from plasma obtained at enrollment in pediatric participants in NASH Clinical Research Network studies with liver biopsy-proven NAFLD. Cytokines were chosen a priori as possible discriminators of NASH and its components. Minimization of Akaike Information Criterion (AIC) was used to determine cytokines retained in multivariable models.

Resu

SUBMITTER: Perito ER 

PROVIDER: S-EPMC5679472 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature