Sequence-based information-theoretic features for gene essentiality prediction.

ABSTRACT:

Background

Identification of essential genes is not only useful for our understanding of the minimal gene set required for cellular life but also aids the identification of novel drug targets in pathogens. In this work, we present a simple and effective gene essentiality prediction method using information-theoretic features that are derived exclusively from the gene sequences.

Results

We developed a Random Forest classifier and performed an extensive model performance evaluation among and within 15 selected bacteria. In intra-organism predictions, where training and testing sets are taken from the same organism, AUC (Area Under the Curve) scores ranging from 0.73 to 0.90, 0.84 on average, were obtained. Cross-organism predictions using 5-fold cross-validation, pairwise, lea

SUBMITTER: Nigatu D 

PROVIDER: S-EPMC5679510 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature