Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension.

ABSTRACT:

Objective

In order to search for metabolic biomarkers of antihypertensive drug responsiveness, we measured >600 biochemicals in plasma samples of subjects participating in the GENRES Study. Hypertensive men received in a double-blind rotational fashion amlodipine, bisoprolol, hydrochlorothiazide and losartan, each as a monotherapy for one month, with intervening one-month placebo cycles.

Methods

Metabolomic analysis was carried out using ultra high performance liquid chromatography-tandem mass spectrometry. Full metabolomic signatures (the drug cycles and the mean of the 3 placebo cycles) became available in 38 to 42 patients for each drug. Blood pressure was monitored by 24-h recordings.

Results

Amlodipine (P values down to 0.002), bisoprolol (P values down to 2 x 10

SUBMITTER: Hiltunen TP 

PROVIDER: S-EPMC5679533 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature