Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice.

ABSTRACT:

Object

To develop and evaluate a 2D modified Look-Locker (MOLLI) for high-resolution T1 mapping in mice using a 3T MRI scanner.

Materials and methods

To allow high-resolution T1 mapping in mice at high heart rates a multi-shot ECG-triggered 2D MOLLI sequence was developed. In the proposed T1 mapping sequence the optimal number of sampling points and pause cardiac cycles following an initial adiabatic inversion pulse was investigated in a phantom. Seven native control and eight mice, 3 days post myocardial infarction (MI) after administration of gadolinium were scanned. Two experienced readers graded the visual T1 map quality.

Results

In T1 phantoms, there were no significant differences (<0.4% error) between 12, 15 and 20 pause cardiac cycles (p = 0.1, 0.2 and 0.6 res

SUBMITTER: Nezafat M 

PROVIDER: S-EPMC5679534 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature