Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication.

ABSTRACT: Salmonella enterica serovar typhimurium extensively remodels the host late endocytic compartments to establish its vacuolar niche within the host cells conducive for its replication, also known as the Salmonella-containing vacuole (SCV). By maintaining a prolonged interaction with late endosomes and lysosomes of the host cells in the form of interconnected network of tubules (Salmonella-induced filaments or SIFs), Salmonella gains access to both membrane and fluid-phase cargo from these compartments. This is essential for maintaining SCV membrane integrity and for bacterial intravacuolar nutrition. Here, we have identified the multisubunit lysosomal tethering factor-HOPS (HOmotypic fusion and Protein Sorting) complex as a crucial host factor facilitating delivery of late endosomal and lyso

SUBMITTER: Sindhwani A 

PROVIDER: S-EPMC5679646 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature