Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein.

ABSTRACT:

Background

The adaptive cytotoxic T lymphocyte (CTL)-mediated immune response is critical for clearance of many viral infections. These CTL recognize naturally processed short viral antigenic peptides bound to human leukocyte antigen (HLA) class I molecules on the surface of infected cells. This specific recognition allows the killing of virus-infected cells. The T cell immune T cell response to Chikungunya virus (CHIKV), a mosquito-borne Alphavirus of the Togaviridae family responsible for severe musculoskeletal disorders, has not been fully defined; nonetheless, the importance of HLA class I-restricted immune response in this virus has been hypothesized.

Methodology/principal findings

By infection of HLA-A*0201-transgenic mice with a recombinant vaccinia virus that encodes

SUBMITTER: Lorente E 

PROVIDER: S-EPMC5679651 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature