Unknown

Dataset Information

0

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

ABSTRACT: Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005

SUBMITTER: Davis JP 

PROVIDER: S-EPMC5679656 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established lo  ...[more]

Similar Datasets

Unknown Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort.
| S-EPMC11432478 | biostudies-literature
Unknown Triglyceride content of lipoprotein subclasses and kidney hemodynamic function and injury in adolescents with type 1 diabetes.
| S-EPMC10176326 | biostudies-literature
Unknown Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation.
| S-EPMC6485081 | biostudies-literature
Unknown Effects of lipid-lowering drugs on high-density lipoprotein subclasses in healthy men-a randomized trial.
| S-EPMC3963857 | biostudies-literature
Unknown Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
| S-EPMC5905595 | biostudies-literature
Unknown Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study.
| S-EPMC3800263 | biostudies-literature
Transcriptomics Subcutaneous adipose gene expression from men in the METSIM cohort
2019-07-31 | GSE135134 | GEO
Unknown Lipoprotein particle subclasses, cardiovascular disease and HIV infection.
| S-EPMC2818719 | biostudies-literature
Unknown Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
| S-EPMC8661833 | biostudies-literature
Unknown Plasma PCSK9 correlates with apoB-48-containing triglyceride-rich lipoprotein production in men with insulin resistance.
| S-EPMC6071769 | biostudies-literature