Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination.

ABSTRACT: The alkynylation of naphthols takes place with total regiocontrol at the peri position of the hydroxyl group in the presence of [RuCl₂(p-cymene)]₂ as the catalyst. This reaction features high functional group tolerance. The related ortho-alkynylation of benzoic acids proceeds under similar conditions and also shows wide functional group tolerance. Both reactions proceed through metalation, insertion of the alkyne, and bromide elimination.

SUBMITTER: Tan E 

PROVIDER: S-EPMC5679662 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature