Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo.

ABSTRACT:

Background

Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities.

Objectives

The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo.

Methods

Male Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3.0 ml/kg body weight (BW)}, atazanavir (133 mg/kg BW), saquinavir (333 mg/kg BW) with or without naringin (50 mg/kg BW), respectively for 56 days. Body weights and water consumption were recorded daily. Glucose tolerance tests w

SUBMITTER: Nzuza S 

PROVIDER: S-EPMC5679664 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature