Effect of Adolescent Bariatric Surgery on the Brain and Cognition: A Pilot Study.

ABSTRACT:

Objective

Neurocognitive deficits in pediatric obesity relate to poor developmental outcomes. We sought preliminary evidence for changes in brain and cognitive functioning relevant to obesogenic behavior following vertical sleeve gastrectomy (VSG) in adolescents relative to wait-listed (WL) and healthy controls (HC).

Methods

Thirty-six adolescents underwent fMRI twice 4 months apart, during executive, reward, and episodic memory encoding, in addition to behavioral testing for reward-related decision making.

Results

VSG adolescents lost weight, while WL gained weight and HC did not change between time points. Gains in executive and reward-related performance were larger in VSG than control groups. Group × Time interaction (P < 0.05 corrected) in left prefrontal cortex

SUBMITTER: Pearce AL 

PROVIDER: S-EPMC5679722 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature