Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers.

ABSTRACT:

Background

The presence of tumor infiltrating lymphocytes (TIL) is associated with favorable prognosis. Recent evidence suggested that not only their density, but also the spatial organization as tertiary lymphoid structures (TLS), play a key role in determining patient survival.

Materials and methods

In a cohort of 248 breast cancers, the clinicopathologic association and prognostic role of TLS was examined.

Results

Tertiary lymphoid structures were associated with higher tumor grade, apocrine phenotype, necrosis, extensive in situ component, lymphovascular invasion (LVI), and high TIL. For biomarkers, TLS were associated with hormone receptors negativity, HER2 positivity, and c-kit expression. Tertiary lymphoid structures were significantly related to better disease

SUBMITTER: Liu X 

PROVIDER: S-EPMC5679825 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature