Age and Tumor Volume Predict Growth of Carotid and Vagal Body Paragangliomas.

ABSTRACT: Objective  Treatment for head and neck paragangliomas (HNGPL) can be more harmful than the disease. After diagnosis, an initial period of surveillance is often indicated, and surgery or radiotherapy is reserved for progressive disease. With the aim to optimize this "wait and scan" strategy, we studied growth and possible predictors. Design  A retrospective cohort study was conducted. Setting  This study was conducted at a tertiary referral center for patients with HNGPL. Methods  Tumor volume was estimated for 184 SDHD -related carotid and vagal body paragangliomas using sequential magnetic resonance imaging. Cox regression was used to study predictors of tumor growth. Results  The estimated fraction of growing tumors ranged from 0.42 after 1 year of follow-up to 0.85 after 11 years. A med

SUBMITTER: Heesterman BL 

PROVIDER: S-EPMC5680030 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature