Comparative effectiveness of dual vs. single-action antidepressants on HIV clinical outcomes in HIV-infected people with depression.

ABSTRACT:

Objective

Depression is highly prevalent among people living with HIV/AIDS (PLWHA) and has deleterious effects on HIV clinical outcomes. We examined changes in depression symptoms, viral suppression, and CD4 T cells/μl among PLWHA diagnosed with depression who initiated antidepressant treatment during routine care, and compared the effectiveness of dual-action and single-action antidepressants for improving those outcomes.

Design

Comparative effectiveness study of new user dual-action or single-action antidepressant treatment episodes occurring from 2004 to 2014 obtained from the Center for AIDS Research Network of Integrated Clinical Systems.

Methods

We identified new user treatment episodes with no antidepressant use in the preceding 90 days. We completed intent-to-

SUBMITTER: Mills JC 

PROVIDER: S-EPMC5680130 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature