Measuring the Conformational Distance of GPCR-related Proteins Using a Joint-based Descriptor.

ABSTRACT: Joint-based descriptor is a new level of macroscopic descriptor for protein structure using joints of secondary structures as a basic element. Here, we propose how the joint-based descriptor can be applied to examine the conformational distances or differences of transmembrane (TM) proteins. Specifically, we performed three independent studies that measured the global and conformational distances between GPCR A family and its related structures. First, the conformational distances of GPCR A family and other 7TM proteins were evaluated. This provided the information on the distant and close families or superfamilies to GPCR A family and permitted the identification of conserved local conformations. Second, computational models of GPCR A family proteins were validated, which enabled us to es

SUBMITTER: Thangappan J 

PROVIDER: S-EPMC5680341 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature