Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer.

ABSTRACT:

Background

Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer.

Methods

mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes.

Results

One hundred ninety-one patients were included. Median time from completion of neoadjuvant treatment to pre-operative MRI and surgery was 4.1 weeks (interquartile range (IQR): 3.7-4.7) and 6.6 weeks (IQR: 5.9-7.6), respectively. Fair agreement was found between mrTRG and pTRG when regression was classified according to standard five-tier systems (κ=0.24)

SUBMITTER: Sclafani F 

PROVIDER: S-EPMC5680467 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature