STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO₂ gradient.

ABSTRACT: Hypobaric hypoxia elicits several patho-physiological manifestations, some of which are known to be lethal. Among various molecular mechanisms proposed so far, perturbation in redox state due to imbalance between radical generation and antioxidant defence is promising. These molecular events are also related to hypoxic status of cancer cells and therefore its understanding has extended clinical advantage beyond high altitude hypoxia. In present study, however, the focus was to understand and propose a model for rapid acclimatization of high altitude visitors to enhance their performance based on molecular changes. We considered using simulated hypobaric hypoxia at some established thresholds of high altitude stratification based on known physiological effects. Previous studies have focused

SUBMITTER: Paul S 

PROVIDER: S-EPMC5680518 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature