Response to inhaled loxapine in patients with schizophrenia or bipolar I disorder: PANSS-EC responder analyses.

ABSTRACT:

Background

Efficacy of inhaled loxapine 5 or 10 mg in treating agitation was shown using the Positive and Negative Syndrome Scale - Excited Component (PANSS-EC) in two Phase III randomised, double-blind, placebo-controlled trials in 344 agitated patients with schizophrenia and 314 patients with bipolar I disorder (Clinicaltrials.gov: NCT00628589, NCT00721955).

Aims

To examine the five individual items comprising the PANSS-EC and the percentage of patients achieving a clinical response (reduction of ≥40%) in PANSS-EC (Response-40) for these two studies.

Method

Response-40 was examined at the primary end-point (2 h) and over time.

Results

Response-40 and each PANSS-EC item score were statistically significant v. placebo at 2 h and at each assessment time p

SUBMITTER: Zeller S 

PROVIDER: S-EPMC5680528 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature