Profiling the immunome of little brown myotis provides a yardstick for measuring the genetic response to white-nose syndrome.

ABSTRACT: White-nose syndrome (WNS) has devastated populations of hibernating bats in eastern North America, leading to emergency conservation listings for several species including the previously ubiquitous little brown myotis (Myotis lucifugus). However, some bat populations near the epicenter of the WNS panzootic appear to be stabilizing after initial precipitous declines, which could reflect a selective immunogenetic sweep. To investigate the hypothesis that WNS exerts significant selection on the immunome of affected bat populations, we developed a novel, high-throughput sequence capture assay targeting 138 adaptive, intrinsic, and innate immunity genes of putative adaptive significance, as well as their respective regulatory regions (~370 kbp of genomic sequence/individual). We used the

SUBMITTER: Donaldson ME 

PROVIDER: S-EPMC5680615 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature