Defeat mutant KRAS with synthetic lethality.

ABSTRACT: Ras proteins are considered as the founding members of a large superfamily of small GTPases that control fundamental cellular functions. Mutationally activated RAS genes were discovered in human cancer cells more than 3 decades ago, but intensive efforts on Ras structure, biochemistry, function and signaling continue even now. Because mutant Ras proteins are inherently difficult to inhibit and have yet been therapeutically conquered, it was designated as "the Everest of oncogenes" in the cancer genome landscape, further promoting a "renaissance" in RAS research. Different paths to directly or indirectly targeting mutant Ras signaling are currently under investigation in the hope of finding an efficacious regimen. Inhibitors directly binding to KRAS^G12C to block its downstream si

SUBMITTER: Pang X 

PROVIDER: S-EPMC5680709 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature