Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.

ABSTRACT: Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integra

SUBMITTER: Cancer Genome Atlas Research Network. Electronic address: [e-mail] 

PROVIDER: S-EPMC5680778 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature