Young donor white blood cell immunotherapy induces extensive tumor necrosis in advanced-stage solid tumors.

ABSTRACT:

Background

In the past decade, a variety of immunotherapy approaches focused predominantly on the adaptive immune system have shown unprecedented responses in patients with advanced-stage malignancies. However, studies in spontaneous regression/complete resistance (SR/CR) mice and humans have shown a novel innate cancer-killing activity mediated by granulocytes, which is completely transferable for prevention or therapy against established malignancies.

Methods

Three patients with advanced, relapsed or refractory solid tumors for which no standard therapy was available or was refused were enrolled into this ongoing combined phase I/II open label clinical trial testing the safety, dose tolerance, and possible antineoplastic efficacy of sequential infusions of HLA-mismatched n

SUBMITTER: Maharaj D 

PROVIDER: S-EPMC5680985 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature