Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.

ABSTRACT: The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune system. Herein, we characterise the S. mansoni adult male worm secretome and identify 111 proteins, including 7 vaccine candidates and several molecules with potential immunomodulatory activity. Amongst the molecules present in the secretome, a 17-19kDa protein analogous to human cyclophilin A was identified. Given the ability of cyclophilin A to modulate the immune system by regulating antigen presenting cell activity, we sought to determine whether recombinant S. mansoni Cyclophilin A (rSmCypA) is capable of modulating bone-marrow derived dendritic cell (B

SUBMITTER: Floudas A 

PROVIDER: S-EPMC5681295 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature