Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors.

ABSTRACT:

Background

PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation.

Objectives

We tested the hypothesis that dopamine agonists differentially alter mesocortical and mesolimbic network activity in patients with impulsive-compulsive behaviors.

Methods

Dopamine agonist effects on neuronal metabolism were quantified using arterial-spin-labeling MRI measures of cerebral blood flow in the on-dopamine agonist and off-dopamine states. T

SUBMITTER: Claassen DO 

PROVIDER: S-EPMC5681361 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature