Statins for Primary Prevention of Cardiovascular Events and Mortality in Older Men.

ABSTRACT:

Background/objectives

We sought to determine whether statin use for primary prevention is associated with a lower risk of cardiovascular events or mortality in older men.

Design

Prospective cohort study.

Setting

Physicians' Health Study participants.

Participants

7,213 male physicians ≥70 years without a history of cardiovascular disease (CVD).

Measurements

Multivariable propensity score for statin use with greedy matching (1:1) to minimize confounding by indication.

Results

Median baseline age was 77 (70-102), median follow-up was 7 years. Non-users were matched to 1,130 statin users. Statin use was associated with an 18% lower risk of all-cause mortality, HR 0.82 (95% CI 0.69-0.98) and non-significant lower risk of CVD events, HR 0.86 (95% CI 0.

SUBMITTER: Orkaby AR 

PROVIDER: S-EPMC5681374 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature