Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

ABSTRACT:

Rationale

Cortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early-stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied to patients.

Objective

To determine whether post-MI transendocardial injection of allogeneic CBSCs reduces pathological structural and functional remodeling and prevents the development of heart failure in a swine MI model.

Methods and results

Female Göttingen swine underwent left anterior descending coronary artery occlusion, followed by reperfusion (ischemia-reperfusion MI). A

SUBMITTER: Sharp TE 

PROVIDER: S-EPMC5681384 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature