Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves.

ABSTRACT:

Ethnopharmacological relevance

Artemisia annua has been used for > 2000yrs to treat fever and is more recently known for producing the important antimalarial drug, artemisinin.

Aim of the study

Artemisinin combination therapies (ACTs) are effective for treating malaria, but are often unavailable to those in need. Dried leaves of A. annua (DLA) have recently been studied as a cost effective alternative to traditional ACTs. DLA was shown to dramatically increase oral bioavailability compared to pure artemisinin, so more investigation into the mechanisms causing this increased bioavailability is needed.

Materials and methods

In this study, we used a simulated digestion system coupled with Caco-2 cell permeability assays to investigate the intestinal permeability of DLA c

SUBMITTER: Desrosiers MR 

PROVIDER: S-EPMC5681399 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature