Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction.

ABSTRACT: OBJECTIVES:To evaluate the effects of an aldosterone antagonist on exercise intolerance in older adults with heart failure and preserved ejection fraction (HFpEF). DESIGN:Randomized, placebo-controlled, double-blind trial. SETTING:Academic medical center, Winston-Salem, North Carolina. PARTICIPANTS:Older adults (N = 80, aged 71 ± 1; 80% female) with stable compensated HFpEF and controlled blood pressure (BP). MEASUREMENTS:Participants were randomized into a 9-month treatment of spironolactone 25 mg/d vs placebo. Assessments were peak exercise oxygen consumption (VO2 ), 6-minute walk test, Minnesota Living with Heart Failure Questionnaire (MLHFQ), cardiac magnetic resonance imaging, Doppler echocardiography, and vascular ultrasound. RESULTS:Seventy-one participants completed the trial: 37 i

SUBMITTER: Upadhya B 

PROVIDER: S-EPMC5681414 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature