Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage.

ABSTRACT:

Study design

To assess whether warfarin dose requirement, anticoagulation control, and risk of hemorrhage differ in kidney transplant recipients (KTRs) compared with patients without kidney transplants (non-KTRs).

Design

Analysis of data from the Warfarin Pharmacogenetics Cohort, a prospective cohort of first-time warfarin users followed at two anticoagulation clinics.

Setting

Two outpatient anticoagulation clinics at two large, academic, tertiary care hospitals.

Patients

Adults aged 20 years or older starting warfarin for anticoagulation with a therapeutic international normalized ratio (INR) goal of 2-3 who were KTRs (n=65) or non-KTRs (n=1630).

Measurements and main results

Warfarin dose requirement, anticoagulation control, and risk of hemorrhage wer

SUBMITTER: Yanik MV 

PROVIDER: S-EPMC5681429 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature