Mitochondrial gene polymorphism is associated with gut microbial communities in mice.

ABSTRACT: Gut microbial communities are key mediators of health and disease and have the capacity to drive the pathogenesis of diverse complex diseases including metabolic and chronic inflammatory diseases as well as aging. Host genetics is also a major determinant of disease phenotypes, whereby two different genomes play a role, the nuclear (nDNA)- and mitochondrial genome (mtDNA). We investigated the impact of mutations in mtDNA on the gut microbiota using conplastic mouse strains exhibiting distinct mutations in their mtDNA on an identical nDNA. Each of three strain tested harbors a distinct gut microbiota, ranging from differences at the phylum- to operational taxonomic units level. The C57BL/6J-mt ^FVB/NJ strain, carrying a mutation in the mitochondrial ATP8 synthase gene, exhibits hi

SUBMITTER: Hirose M 

PROVIDER: S-EPMC5681637 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature