Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.

ABSTRACT:

Rationale

Effective immunomodulatory therapies for children with life-threatening "cytokine storm" triggered by acute influenza infection are lacking. Understanding the immune profiles of children progressing to severe lung injury and/or septic shock could provide insight into pathogenesis.

Objectives

To compare the endotracheal and serum cytokine profiles of children with influenza-related critical illness and to identify their associations with severe influenza-associated complications.

Methods

Children with influenza-related critical illness were enrolled across 32 hospitals in development (N = 171) and validation (N = 73) cohorts (December 2008 through May 2016). Concentrations of 42 cytokines were measured in serum and endotracheal samples and clust

SUBMITTER: Fiore-Gartland A 

PROVIDER: S-EPMC5681736 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature