Chromatin organization changes during the establishment and maintenance of the postmitotic state.

ABSTRACT:

Background

Genome organization changes during development as cells differentiate. Chromatin motion becomes increasingly constrained and heterochromatin clusters as cells become restricted in their developmental potential. These changes coincide with slowing of the cell cycle, which can also influence chromatin organization and dynamics. Terminal differentiation is often coupled with permanent exit from the cell cycle, and existing data suggest a close relationship between a repressive chromatin structure and silencing of the cell cycle in postmitotic cells. Heterochromatin clustering could also contribute to stable gene repression to maintain terminal differentiation or cell cycle exit, but whether clustering is initiated by differentiation, cell cycle changes, or both is unclear.

SUBMITTER: Ma Y 

PROVIDER: S-EPMC5681785 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature