Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors.

ABSTRACT:

Background

While cure rates for childhood acute lymphoblastic leukemia (cALL) now exceed 80%, over 60% of survivors will face treatment-related long-term sequelae, including cardiometabolic complications such as obesity, insulin resistance, dyslipidemia and hypertension. Although genetic susceptibility contributes to the development of these problems, there are very few studies that have so far addressed this issue in a cALL survivorship context.

Methods

In this study, we aimed at evaluating the associations between common and rare genetic variants and long-term cardiometabolic complications in survivors of cALL. We examined the cardiometabolic profile and performed whole-exome sequencing in 209 cALL survivors from the PETALE cohort. Variants associated with cardiometabolic

SUBMITTER: England J 

PROVIDER: S-EPMC5681795 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature