A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait.

ABSTRACT:

Background

Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the articular cartilage and joint laxity resulting in osteoarthritis. It is a complex disorder having environmental and genetic causes. Existing techniques fail to detect milder forms of DDH in newborns leading to hip osteoarthritis in young adults. A sensitive, specific and cost effective test would allow identification of newborns that could be non-invasively corrected by the use of a Pavlik harness. Previously, we identified a 2.5 MB candidate region on human chromosome 3 by using linkage analysis of a 4 generation, 72 member family. Whole exome sequencing of the DNA of 4

SUBMITTER: Feldman G 

PROVIDER: S-EPMC5681830 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature