Flibanserin-Stimulated Partner Grooming Reflects Brain Metabolism Changes in Female Marmosets.

ABSTRACT:

Introduction

Female sexual interest and arousal disorder is personally distressing for women. To better understand the mechanism of the candidate therapeutic, flibanserin, we determined its effects on an index of brain glucose metabolism.

Aim

We hypothesized that chronic treatment with flibanserin would alter metabolism in brain regions associated with serotonergic function and female sexual behavior.

Methods

In a crossover design, eight adult female common marmosets (Calithrix jacchus) received daily flibanserin or vehicle. After 7-12 weeks of treatment, the glucose metabolism radiotracer [(18) F]fluorodeoxyglucose (FDG) was administered to each female immediately prior to 30 minutes of interaction with her male pairmate, after which females were anesthetized and ima

SUBMITTER: Converse AK 

PROVIDER: S-EPMC5681869 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature