A Review of Pathway-Based Analysis Tools That Visualize Genetic Variants.

ABSTRACT: Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological processes in which the affected genes and proteins are involved. Such analyses support an interactive evaluation of the possible effects of variations on function, regulation or interaction of gene products. Current pathway analysis software often does not support data visualization of variants in pathways as an alternate method to interpret genetic association results, and specific statistical methods for pathway analysis of SNP data are not combined with these visualization f

SUBMITTER: Cirillo E 

PROVIDER: S-EPMC5681904 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature