Nicotine Population Pharmacokinetics in Healthy Adult Smokers: A Retrospective Analysis.

ABSTRACT:

Background and objective

Characterizing nicotine pharmacokinetics is challenging in the presence of background exposure. We performed a combined retrospective population pharmacokinetic analysis of 8 trials, including exposure to Tobacco Heating System and cigarettes (both inhaled), nicotine nasal spray and oral nicotine gum.

Method

Data from 4 single product use trials were used to develop a population pharmacokinetic model with Phoenix^® NLME™ and to derive exposure parameters. Data from 4 separate ad libitum use studies were used for external validation. A total of 702 healthy adult smokers (54% males; 21-66 years of age; smoking ≥10 cigarettes/day; from US, Europe and Japan) were eligible for participation.

Results

Two-compartment linear disposition comb

SUBMITTER: Marchand M 

PROVIDER: S-EPMC5681983 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature