Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs.

ABSTRACT: Transformed plasma cells in multiple myeloma (MM) are susceptible to natural killer (NK) cell-mediated killing via engagement of tumor ligands for NK activating receptors or "missing-self" recognition. Similar to other cancers, MM targets may elude NK cell immunosurveillance by reprogramming tumor microenvironment and editing cell surface antigen repertoire. Along disease continuum, these effects collectively result in a progressive decline of NK cell immunity, a phenomenon increasingly recognized as a critical determinant of MM progression. In recent years, unprecedented efforts in drug development and experimental research have brought about emergence of novel therapeutic interventions with the potential to override MM-induced NK cell immunosuppression. These NK-cell enhancing tre

SUBMITTER: Pittari G 

PROVIDER: S-EPMC5682004 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature