Combined soft and skeletal tissue modelling of normal and dysmorphic midface postnatal development.

ABSTRACT:

Background

Midface hypoplasia as exemplified by Treacher Collins Syndrome (TCS) can impair appearance and function. Reconstruction involves multiple invasive surgeries with variable long-term outcomes. This study aims to describe normal and dysmorphic midface postnatal development through combined modelling of skeletal and soft tissues and to develop a surgical evaluation tool.

Materials and methods

Midface skeletal and soft tissue surfaces were extracted from computed tomography scans of 52 control and 14 TCS children, then analysed using dense surface modelling. The model was used to describe midface growth, morphology, and asymmetry, then evaluate postoperative outcomes.

Results

Parameters responsible for the greatest variation in midface size and shape showed diff

SUBMITTER: Ibrahim A 

PROVIDER: S-EPMC5682025 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature