Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer.

ABSTRACT:

Background

The epidermal growth factor (EGF) is recognized medicine of therapy in ulcer. However, its efficacy has been challenged. We compared scorpion venom active polypeptide and EGF of therapeutic effects in diabetic ulcer.

Methods

The scorpion venom active polypeptide is made into gel. Fourteen diabetic SD rats were randomly divided into scorpion peptide gel group (SPG group) and EGF group. Before treatment, the rat model of diabetic ulcer was created. The levels of IL-1, IL-6, IL-8, and TNF-α in the wound tissue were measured at different time points during the treatment, secretions of wound were collected for bacterial culture, and the wound healing was recorded.

Results

Wound healing was faster in SPG group compared to EGF group (3 weeks versus 5 weeks,

SUBMITTER: Wan T 

PROVIDER: S-EPMC5682090 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature