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Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4⁺ T Cell Effector Responses and Induces CD25⁺Foxp3⁺ T Regulatory Subsets.

ABSTRACT: Allograft inflammatory factor-1 (AIF1) is a cytoplasmic scaffold protein shown to influence immune responses in macrophages and microglial cells. The protein contains Ca²⁺ binding EF-hand and PDZ interaction domains important for mediating intracellular signaling complexes. This study now reports that AIF1 is expressed in CD11c⁺ dendritic cells (DC) and silencing of expression restrains induction of antigen-specific CD4⁺ T cell effector responses. AIF1 knockdown in murine DC resulted in impaired T cell proliferation and skewed polarization away from T helper type 1 and 17 fates. In turn, there was a parallel expansion of IL-10-producing and CD25⁺Foxp3⁺ T regulatory subsets. These studies are the first to demonstrate that AIF1 expressio

SUBMITTER: Elizondo DM

PROVIDER: S-EPMC5682305 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4⁺ T Cell Effector Responses and Induces CD25⁺Foxp3⁺ T Regulatory Subsets.

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Dataset Information

Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4+ T Cell Effector Responses and Induces CD25+Foxp3+ T Regulatory Subsets.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4⁺ T Cell Effector Responses and Induces CD25⁺Foxp3⁺ T Regulatory Subsets.