LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation.

ABSTRACT: Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking - an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces primary process thinking under placebo-controlled, standardized experimental conditions and whether these effects are related to subjective experience and 5-HT2A receptor activation. Therefore, this study aimed to test the hypotheses that LSD increases primary process thinking and that primary process thinking depends on 5-HT2A receptor activation and is relat

SUBMITTER: Kraehenmann R 

PROVIDER: S-EPMC5682333 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature