Clinical characteristics of 138 Chinese female patients with idiopathic hypogonadotropic hypogonadism.

ABSTRACT:

Objective

To evaluate the clinical features of Chinese women with idiopathic hypogonadotropic hypogonadism (IHH).

Methods

We retrospectively reviewed the clinical characteristics, laboratory and imaging findings, therapeutic management and fertility outcomes of 138 women with IHH. All patients had been treated and followed up at an academic medical centre during 1990-2016.

Results

Among the 138 patients, 82 patients (59.4%) were diagnosed with normosmic IHH and 56 patients (40.6%) were diagnosed with Kallmann syndrome (KS). The patients with IHH experienced occasional menses (4.3%), spontaneous thelarche (45.7%) or spontaneous pubarche (50.7%). Women with thelarche had a higher percentage of pubarche (P  < 0.001) and higher gonadotropin concentrations (<

SUBMITTER: Tang RY 

PROVIDER: S-EPMC5682410 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature