Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up.

ABSTRACT: We previously found that electrical stimulation in the anterior limb of the internal capsule/bed nucleus of the stria terminalis (IC/BST) alleviates depressive symptoms in severe treatment-resistant obsessive-compulsive disorder (OCD) patients. Here we tested the hypothesis that electrical stimulation in either IC/BST or in the inferior thalamic peduncle (ITP) effectively reduces depressive symptoms in treatment-resistant major depressive disorder (TRD). In a double-blind crossover design, the effects of electrical stimulation at both targets were compared in TRD patients. The 17-item Hamilton Depression Rating scale (HAM-D) was the primary outcome measure. During the first crossover, patients received IC/BST stimulation versus no stimulation in random order (2 × 1 weeks). During the secon

SUBMITTER: Raymaekers S 

PROVIDER: S-EPMC5682606 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature