Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.

ABSTRACT: Tenomodulin (Tnmd) is the best-known mature marker for tendon and ligament lineage cells. It is important for tendon maturation, running performance and has key implications for the resident tendon stem/progenitor cells (TSPCs). However, its exact functions during the tendon repair process still remain elusive. Here, we established an Achilles tendon injury model in a Tnmd knockout (Tnmd^-/-) mouse line. Detailed analyses showed not only a very different scar organization with a clearly reduced cell proliferation and expression of certain tendon-related genes, but also increased cell apoptosis, adipocyte and blood vessel accumulation in the early phase of tendon healing compared with their wild-type (WT) littermates. In addition, Tnmd^-/- tendon scar tissue contained au

SUBMITTER: Lin D 

PROVIDER: S-EPMC5682675 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature