Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.

ABSTRACT: Caspase-2 has been shown to be involved in metabolic homeostasis. Here, we show that caspase-2 deficiency alters basal energy metabolism by shifting the balance in fuel choice from fatty acid to carbohydrate usage. At 4 weeks of age, whole-body carbohydrate utilisation was increased in Casp2^-/- mice and was maintained into adulthood. By 17 weeks of age, Casp2^-/- mice had reduced white adipose mass, smaller white adipocytes decreased fasting blood glucose and plasma triglycerides but maintained normal insulin levels. When placed on a 12-week high-fat diet (HFD), Casp2^-/- mice resisted the development of obesity, fatty liver, hyperinsulinemia and insulin resistance. In addition, HFD-fed Casp2^-/- mice had reduced white adipocyte hypertrophy, apoptos

SUBMITTER: Wilson CH 

PROVIDER: S-EPMC5682682 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature