Efficacy and Safety of Tacrolimus in Myasthenia Gravis: A Systematic Review and Meta-analysis.

ABSTRACT:

Aims

This study was designed to determine whether treatments with tacrolimus would provide benefit for patients with myasthenia gravis (MG).

Materials and methods

The databases of Medline, EMBASE, the Cochrane Library, and four Chinese databases were searched for eligible studies. Weighted mean differences and standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were used to summarize the primary outcome, namely, steroid-sparing effect of tacrolimus in maintaining minimal manifestations, and the secondary outcome, namely, the effect of tacrolimus in reducing the severity of MG, respectively.

Results

After systematic retrieval, 13 researches with two randomized controlled trials (RCTs) and 11 prospective open-label single-arm clinical t

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC5682735 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature